Case of the month - December 2006
History:
- 50 year old female - recurrent lump in breast - wide excision biopsy of 5 cm mass
Macro view of two slices of the lesion of the lesion

Low power view (x 1.25) of approximately one quarter of the lesion
Note the relationship between the edge of the lesion and adjacent normal breast tissue

Medium power view (x 20) showing stromal-epithelial relationship
'Mouse over' for high power (x40) view

Medium power view (x 20) showing stromal-epithelial relationship - second area
'Mouse over' for high power (x40) view - note frequent stromal mitoses

High power view (x 40) showing detail of stromal element of the lesion
Note mitotic figure (arrow) and multinucleate giant cells

High power views of bizarre mitoses in stromal cells
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- What are the main features in this biopsy?
- Are there any additional stains that might help you with the diagnosis?
- What is your diagnosis?