Diagnosis - High grade ductal carcinoma in situ (DCIS) with comedo necrosis

Features to note:


• Collection of duct structures with central area of necrotic debris and surrounding zone of high grade malignant epithelial cells



• Epithelium confined to duct structures with no dfinite evi8dence of invasion/microinvasion of surrounding stroma



• In contrast to benign or atypical epithelial proliferations there is no co-proliferation of myopethial cells in DCIS - can be shown with immuno

See also Carcinoma in situ