Detail from image above: The 'microglandular adenosis' acini are on the left and are composed of a single layer of cuboidal epithelial cells with pink luminal secretions. Please note the contrast with the adjacent two layered sclerosed lobule (A).
'Mouse over' shows further detail. A focus of apocrine metaplasia is present on the left (B)
See also Sclerosing Lesions.
Notes
- Microglandular adenosis is a very rare benign condition that can be easily mistaken for low grade carcinoma, particularly as a bounding myoepithelial layer is absent
- Atypical variants are recognised
- The cells show positive immuno staining with S100, CK 8/18 & EGFR and negative staining for ER, PGR & Her-2
- Immuno stains for Collagen IV or laminin are usually positive indicating an intact bounding basement membrane
- There is an association with atypical proliferations and malignancy in up to 50% of cases
See also Sclerosing Lesions.
Acknowledgement:
I am extremely grateful to Dr Mark Ashton, Consultant Pathologist, Raigmore Hospital, Inverness, who kindly loaned me the section from which these photomicrographs have been taken.
Selected reference:
1. Kempson RL and Rouse RV in Stanford University Definitions.
Return to top of this page
Image of the week index
Return to Home Page
1. Kempson RL and Rouse RV in Stanford University Definitions.
Image of the week index
Return to Home Page